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Multiple Sclerosis
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Article

Peripheral blood leukocyte NO production and oxidative stress in multiple sclerosis

Marcus Koch1*, Jop Mostert1, Alexander Arutjunyan2, Michael Stepanov2, Albert Teelken1, Dorothea Heersema1, and Jacques De Keyser1

1 Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
2 Laboratory of Perinatal Biochemistry, D.O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St Petersburg, Russia

* To whom correspondence should be addressed.


  Abstract

Background The reason for increased peripheral blood leukocyte (PBL) nitric oxide (NO) production in patients with multiple sclerosis (MS) is unknown.

Objective To investigate whether PBL NO production is related to measures of oxidative stress.

Methods PBL nitrite, diene conjugates (DC, a measure of undergone oxidative stress), antiradical activity (ARA) and antioxidant acitvity (AOA) were measured in 35 healthy control persons and 80 patients with MS. We investigated the correlation of these measures with a partial correlation analysis, with age as the control variable.

Results There was a significant correlation in both MS patients and healthy control persons between PBL nitrite levels and PBL DC, ARA and AOA. The correlations were stronger in healthy control persons. An analysis by disease subtype showed that the correlations were present in patients with relapsing–remitting and secondary progressive MS, but absent in primary progressive MS.

Conclusions PBL nitrite levels and measures of oxidative stress are closely related in MS-patients as well as in healthy control persons. Increased serum NO levels in MS may be the result of a physiologic reaction to overall oxidative stress. The differences in the strength of correlation between different disease subtypes may reflect differences in leukocyte biology. Multiple Sclerosis 2007; 00: 00–00. http://msj.sagepub.com

Key Words: multiple sclerosis; oxidative stress; nitric oxide; leukocytes

First published on October 17, 2007, doi:10.1177/1352458507082075

Multiple Sclerosis 2008;14:159.

A more recent version of this article appeared on March 1, 2008

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