Multiple sclerosis and the CTLA4 autoimmunity polymorphism CT60: no association in patients from Germany, Hungary and Poland

¹ Department of General Neurology, Hertie Institute for Clinical Brain Research, Tübingen, Germany
² Department of Neurology, University of Pecs, Hungary
³ Department of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, Poland
⁴ Department of Neurology, Jahn Ferenc Teaching Hospital, Budapest, Hungary
⁵ Department of Immunogenetics, National Medical Center, Budapest, Hungary
⁶ Institute of Anthropology and Human Genetics, University of Tübingen, Germany
⁷ Institute of Epidemiology and Social Medicine, University of Münster, Germany

^* To whom correspondence should be addressed.

	Abstract

Polymorphisms in the CTLA4 gene region have been associated with susceptibility to autoimmune diseases. The recently described single nucleotide polymorphism CT60, located in the 3' untranslated region of CTLA4 is associated with Graves' disease, thyroiditis, autoimmune diabetes and other autoimmune diseases. A case-control association study was conducted in German, Hungarian and Polish multiple sclerosis (MS) patients and regional control individuals for the CTLA4 CT60 and +49A/G polymorphisms. No significant association of these polymorphisms or respective haplotypes with MS was found. No association of CT60 genotypes with T cell expression of ICOS and CTLA-4 after in vitro stimulation was detected.

Key Words: association; CTLA-4; genetics; multiple sclerosis; polymorphism

First published on October 17, 2007, doi:10.1177/1352458507082357

Multiple Sclerosis 2008;14:153.

A more recent version of this article appeared on March 1, 2008


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