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First published on January 21, 2008, doi:10.1177/1352458507082600

Multiple Sclerosis 2008;14:284.

A more recent version of this article appeared on March 1, 2008

Article

The association of multiple sclerosis and Hodgkin's disease: the role of Epstein-Barr virus infection

Mario Habek*, V V Brinar, and Sanja Hajnsek

Referral Center for Demyelinating Diseases of the Central Nervous System, University Department of Neurology, Zagreb School of Medicine and University Hospital Center, Zagreb, Croatia

* To whom correspondence should be addressed.


  Abstract

The aetiology of multiple sclerosis (MS) is still an unresolved question. Several recently reported studies are implicating EpsteinBarr virus (EBV) as one of the key players in MS pathogenesis. We present a 21-year-old male patient with a history of EBV-related infectious mononucleosis in puberty and Hodgkins disease two years previously treated with irradiation and chemotherapy. The patient presented with spastic paraparesis that resolved promptly on corticosteroid treatment. There were no signs of Hodgkins disease relapse. In the next three years he had three more bouts of the disease and he was diagnosed with relapseremitting MS. There is evidence of EBV involvement in MS pathogenesis; the association of MS with EBV-related infectious mononucleosis and Hodgkins disease being just one of them. Although there are many unanswered questions, it is clear that without EBV seropositivity MS in adults is extremely rare.

Key Words: aetiology; EpsteinBarr virus; Hodgkins disease; multiple sclerosis; multiple sclerosis trait


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