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First published on October 17, 2007, doi:10.1177/1352458507082607

Multiple Sclerosis 2008;14:383.

A more recent version of this article appeared on April 1, 2008
 This version was published on January 31, 2008

Article

Evaluation of the six-minute walk in multiple sclerosis subjects and healthy controls

Myla D. Goldman1*, Ruth Ann Marrie2, and J. A. Cohen2

1 Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA
2 The Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH, USA

* To whom correspondence should be addressed.


  Abstract

Objective To assess the characteristics of the 6-min walk (6MW) in multiple sclerosis (MS) subjects of varied disability, and controls. To assess the correlation of 6MW to subjective measures of fatigue, health status and ambulation using the modified fatigue impact scale (MFIS), short form-36 Health Questionnaire physical component score and MS walking scale (MSWS).

Methods Forty MS expanded disability status scale [(EDSS) 0–6.5] and 20 control subjects were recruited from a MS outpatient clinic. Subjects completed survey material and three 6MWs with 1-h interval rest in a single study visit.

Results There was no practice effect or fatigability with repeat 6MW tests with a one-h rest period between test sessions. The 6MW had excellent intra-[intraclass correlation coefficient (ICC)=0.95] and inter-rater (ICC=0.91) reliability. MS subjects demonstrated reduced 6MW distance and speed compared with controls (P<0.0001). Within the MS population 6MW distance was significantly reduced with increasing disability (P=0.05). Compared with the EDSS, the 6MW had a stronger correlation to subjective measures of ambulation and physical fatigue: MSWS (r=-0.81 versus 0.69) and MFISphy (0.66 versus 0.63).

Conclusions The 6MW is a feasible, reproducible, and reliable measure in MS. MS subjects demonstrate motor fatigue in both 6MW distance and speed compared with controls. In MS subjects there is an inverse relationship between motor fatigue and disability. 6MW has a strong correlation to subjective measures of ambulation and physical fatigue.

Key Words: six-minute walk; motor fatigue; outcome measures; multiple sclerosis


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