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First published on January 21, 2008, doi:10.1177/1352458507082617

Multiple Sclerosis 2008;14:248.

A more recent version of this article appeared on March 1, 2008
 This version was published on January 31, 2008

Article

Brain magnetic resonance imaging findings in acuterelapses of neuromyelitis optica spectrum disorders

Jose A Cabrera–Gómez1*, A. Saiz–Hinarejos2, F Graus2, A. González–Quevedo3, R. Rodríguez–Rojas1, L Quevedo–Sotolongo1, Y Real–González4, D. Grass Fernández1, M Cristófol–Corominas1, M.L. Rodriguez–Cordero5, M.A. Robinson–Agramonte1, E. Infante–Velázquez1, A Cabrera–Núñez6, C Ugarte–Sánchez7, J Jordán–González7, J E González De La Nuez7, J García Lahera7, R Tellez7, M. Baez–Martín1, and K. Romero–Garcia1

1 International Neurological Restoration Center (CIREN), Avenida 25 #15805 entre 158 y 160, Reparto Cubanacán,Playa, Ciudad de La Habana, Cuba
2 Service of Neurology Hospital Clinic and Institut d'Investigación Biomèdica August Pi i Sanyer (IAIBAPS), University ofBarcelona, Villarroel 170, 08036 Barcelona, Spain
3 Institute of Neurology and Neurosurgery, 29 y D, Vedado, Havana, Cuba
4 Cira Garcia Clinic, Havana, Cuba
5 1International Neurological Restoration Center (CIREN), Avenida 25 #15805 entre 158 y 160, Reparto Cubanacán,Playa, Ciudad de La Habana, Cuba
6 Dr Raúl Dorticós' School of Medicine, Cienfuegos, Cuba
7 Center of Medical and Surgical Investigations (CIMEQ), Calle 218 entre 13 y 11, Playa Havana, Cuba

* To whom correspondence should be addressed.


  Abstract

We studied cranial magnetic resonance imaging (MRI) lesions in three women with acute attacks ofrecurrent longitudinally extensive transverse myelitis (r–LETM), recurrent–optic neuritis (r–ON) andr–LETM–CNS. Neuromyelitis Optica –immunoglobulin (IgG) antibody was positive in all cases. BrainMRI (1.5 Tesla) was performed according to protocol from consortium MS centre. We described thecranial lesions in brain MRI of acute relapses. These lesions were different from MS, most had an asymptomaticcourse which disappeared with time, protocol from consortium of MS centre criteria for brainMRI and seropositivity of NMO–IgG are useful tools for differentiate acute lesions of NMO/MS.

Key Words: neuromyelitis optica spectrum disorders; recurrent longitudinally extensive transversemyelitis; recurrent optic neuritis


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