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First published on January 21, 2008, doi:10.1177/1352458507083187

Multiple Sclerosis 2008;14:567.

A more recent version of this article appeared on May 1, 2008

Article

Ehlers–Danlos syndrome and multiple sclerosis: a possible association

C S Constantinescu1*, J. Vilisar1, S. Harikrishnan2, and M. Suri1

1 Division of Clinical Neurology, Faculty of Medicine and Health Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, UK
2 Clinical Genetics Service, City Hospital, Nottingham, UK

* To whom correspondence should be addressed.


  Abstract

Ehlers–Danlos syndrome (EDS) has various neurological manifestations. Here we present an association of EDS with multiple sclerosis (MS). Four MS patients from a total of 1892 followed up at our MS outpatient clinics had EDS. This frequency suggests 10–11 times increased prevalence of EDS in MS patients compared with the general population (P _ 0.02). Suggested implications include a possible causal relationship on a connective tissue level with a higher susceptibility to MS in EDS. Diagnostic and management considerations are important in coexisting MS and EDS. Our patients had relatively florid lesions on brain MRIs and typical course and features of MS.

Key Words: autoimmune; connective tissue; Ehlers–Danlos syndrome; extracellular matrix; hypermobility; inflammatory; multiple sclerosis


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