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First published on January 21, 2008, doi:10.1177/1352458507083188

Multiple Sclerosis 2008;14:292.

A more recent version of this article appeared on April 1, 2008

Article

Chlamydia pneumoniae-specific serum immune complexes in patients with multiple sclerosis

John Parratt1*, Roger Tavondale2, Jonathan O'Riordan3, David Parratt4, and Robert Swingler3

1 Department of Neurology, University of Sydney, Blackburn Building, Camperdown, Sydney, NSW 2006, Australia
2 Department of Cardiovascular Epidemiology, University of Dundee, Dundee, UK
3 Department of Neurology, Tayside University Hospitals, Dundee, UK
4 Department of Microbiology, Tayside University Hospitals, Dundee, UK

* To whom correspondence should be addressed.


  Abstract

The significance of Chlamydia pneumoniae infection in patients with multiple sclerosis (MS) is unclear.We determined the frequency of serum C. pneumoniae-specific immune complexes in patients withMS, neurological (OND) and healthy controls in a blinded, cross-sectional study. C. pneumoniaeimmune complexes were detected in 24% (38/156) of MS patients, 16% (11/69) of OND and 15%(77/499) of healthy controls. The odds ratio for all MS patients was 3.95 (95% CI: 2.15 to 7.24;P _ 0.0001) accounting for the covariates: sex, age, socio-economic status and area of residence. Theodds ratio for recently diagnosed MS patients was 4.33 (95% CI: 1.76 to 10.64; P _ 0.001). SystemicC. pneumoniae infection is more frequent in MS patients than the healthy population and occurs earlyin the course of the disease

Key Words: Chlamydia pneumoniae; immune complexes; multiple sclerosis)


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