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1352458507083780v1
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First published on January 21, 2008, doi:10.1177/1352458507083780

Multiple Sclerosis 2008;14:412.

A more recent version of this article appeared on April 1, 2008

Article

Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis

Robert Goertsches1, Sergio E. Baranzini2, Carlos Morcillo3, C Nos1, Montse Camiña1, Jorge R. Oksenberg2, Xavier Montalban1*, and Manuel Comabella4

1 Unitat de Neuroimmunologia Clnica, Hospital Universitari Vall dHebron (HUVH), 08035 Barcelona, Spain
2 Department of Neurology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143-0435, USA
3 Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
4 Unitat de Neuroimmunologia Clnica, Hospital Universitari Vall dHebron (HUVH), 08035 Barcelona, Spain

* To whom correspondence should be addressed.


  Abstract

A recent association study has provided evidence that chromosome 10q22.1 may contain candidate genes for multiple sclerosis (MS). We analysed two intronic and a non-synonymous single nucleotide polymorphism (SNP) of the C10orf27 gene in 571 patients with MS relapsing remitting and primaryprogressive) and healthy controls. Adjusted comparisons revealed significant association with disease susceptibility for one intronic SNP in RRMS individuals and the amino acid modifying SNP for PPMS cases; the latter may also contribute to faster disease progression. Transcript expression in brain lesions from MS patients was increased. These findings suggest C10orf27 as a candidate gene for MS susceptibility and pathogenesis.

Key Words: polymorphism; multiple sclerosis; open reading frame


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