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First published on January 21, 2008, doi:10.1177/1352458507084036

Multiple Sclerosis 2008;14:418.

A more recent version of this article appeared on April 1, 2008
 This version was published on April 4, 2008

Article

Baló's disease showing benign clinical course and co-existence with multiple sclerosis-like lesions among the Chinese

Chaodong Wang, Kun-Nan Zhang, Xiao-Mu Wu*, Gang Huang, Xu-Fang Xie, Xin-Hui Qu, and Ying-Qiong Xiong

Department of Neurology, Jiangxi Provincial People's Hospital, Nanchang 330006, P. R. China

* To whom correspondence should be addressed.


  Abstract

Baló's concentric sclerosis (BCS) is a rare demyelinating disorder usually considered a variant of multiple sclerosis (MS). However, its pathogenesis and its correlation with MS remains unclear and controversial. This report presents seven Hans Chinese subjects diagnosed as BCS on the basis of the pathognomonic MR (magnetic resonance) findings. Upon diagnosis, all the cases displayed good responses to corticosteroids and showed an overall benign prognosis during a follow-up period of 4–13.5 years, although three relapsed later. MR findings suggest that the characteristic concentric lesions of BCS frequently (5/7) coexist with multiple sclerosis-like lesions. During follow-up, the Baló-like lesions may either dissolve over time or transform into an MS-like lesion. Moreover, the Balóand MS-like lesions occurred one after another at the onset and relapse phases of the same patient in two cases. These clinical features suggest that Baló's disease showing benign clinical course and co-existence of multiple sclerosis (MS)-like lesion is not rare among the Chinese, and strengthens the notion that BCS correlates intrinsically with MS.

Key Words: Baló's concentric sclerosis (BCS); magnetic resonance imaging (MRI); multiple sclerosis (MS)


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