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Multiple Sclerosis
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Article

MDC/CCL22 intrathecal levels in patients with multiple sclerosis

Daniela Galimberti1*, C. Fenoglio1, D. Scalabrini2, M. De Riz1, E. Venturelli1, F. Cortini3, M. Piola1, N. Bresolin1, E. Scarpini1, C. Comi2, M. Leone1, and F. Monaco1

1 Department of Neurological Sciences, 'Dino Ferrari' Center, University of Milan, IRCCS Ospedale Maggiore Policlinico,Milan, Italy
2 Department of Neurology, Ospedale Maggiore, University 'Amedeo Avogadro', Novara, Italy and 3Interdisciplinary Research Center of Autoimmune Diseases (IRCAD) and Department of Medical Sciences, 'A. Avogadro'University of Eastern Piedmont, Novara, Italy
3 Department of Neurology, Ospedale Maggiore, University 'Amedeo Avogadro', Novara, Italy

* To whom correspondence should be addressed.


  Abstract

MDC/CCL22 has been detected in the brain of mice with experimental autoimmuneencephalomyelitis. MDC/CCL22 cerebrospinal fluid levels were evaluated in 56 patients with multiplesclerosis (MS) and in 17 controls. No significant differences were found, even when stratifyingpatients according to the disease subtype. Stratifying by gender, significantly increased MDC/CCL22levels were observed in female patients when compared with female controls and male patients(109.03 versus 98.54 and 99.37 pg/mL, P _ 0.034 and 0.018, respectively). Therefore, MDC/CCL22is likely to play a role in the development of MS in females only, possibly influencing the intracerebralrecruitment of Th2 cells, which produce anti-inflammatory cytokines. Multiple Sclerosis 2007;00: 00–00. http://msj.sagepub.com

Key Words: cerebrospinal fluid; MDC/CCL22; multiple sclerosis

First published on January 21, 2008, doi:10.1177/1352458507084268

Multiple Sclerosis 2008;14:547.

A more recent version of this article appeared on May 1, 2008

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