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First published on January 21, 2008, doi:10.1177/1352458507084270

Multiple Sclerosis 2008;14:364.

A more recent version of this article appeared on April 1, 2008

Article

Cognitive deficits in multiple sclerosis correlate with changes in fronto-subcortical tracts

Jorge Correale1*, M. Roca1, M. Fiol2, M. E. Martin1, L. Vita3, F. Meli2, S. Carpintiero2, G. De Pino2, F. Ventrice1, L Vital1, F. Manes1, and M. L. Calcagno1

1 Department of Neurology, Dr Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina
2 Department of Radiology, Dr Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina
3 Department of Statistics, School of Pharmacy and Biochemistry, Buenos Aires University, Buenos Aires, Argentina

* To whom correspondence should be addressed.


  Abstract

Cognitive function and diffusion tensor imaging were assessed in a group of 12 patients with earlyrelapsing–remitting multiple sclerosis (disease duration _3 years), and mild clinical disability(expanded disability status scale _2), as well as in 12 control subjects. Patients showed impairment inimmediate logical memory and delayed recall with the Rey auditory verbal learning test. No significantdifferences in classical executive tests were observed. In contrast, differences were found for specificexecutive tests including IOWA Gambling Task, multiple errands test hospital version (MET) and HotelTask, as well as in Paced-Auditory Serial Addition Test (PASAT). Significant correlation was foundbetween PASAT performance and FA measures (r _ 0.64, P _ 0.03), the apparent diffusion coefficientsand the MET (r _ 0.72, P _ 0.01), as well as in one subtask of Hotel (r_ _0.68, P _ 0.02). Thus, executivedeficits can best be appreciated at early stages of MS when a more specific battery of tests is usedfor patient evaluation. In this series, test failures observed correlated with changes in fronto-subcorticalfiber tracts. Multiple Sclerosis 2007; 00: 00–00. http://msj.sagepub.com

Key Words: multiple sclerosis; frontal lobe; cognitive functions; diffusion tensor MRI


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