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Multiple Sclerosis
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Article

T-1237C polymorphism of TLR9 gene is not associated with multiple sclerosis in the Portuguese population

Fernando Rodrigues1*, A. Carvalho2, M. Santos1, and P. Maciel1

1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
2 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal and 2ICBAS, University of Porto, Porto, Portugal

* To whom correspondence should be addressed.


  Abstract

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, with disturbances of the immunological balance. As TLR9-null mice showed increased resistance to experimental autoimmune encephalomyelitis and recent genetic investigations showed that T-1237C promoter polymorphism of TLR9, commonly implicated in autoimmune diseases, induces a deregulation of its expression, we performed an association study in a Portuguese population of 165 MS patients and unrelated healthy controls. Our results show no significant association with MS and no protective effect of T-1237C concerning age of onset, disease severity or disease subtype in MS patients

Key Words: disease; inflammation; innate immunity; susceptibility; toll-like receptor.

First published on January 21, 2008, doi:10.1177/1352458507084594

Multiple Sclerosis 2008;14:550.

A more recent version of this article appeared on May 1, 2008

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