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Multiple Sclerosis
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Article

Apneusis responding to buspirone in multiple sclerosis

R.J. O’Sullivan1, I.G. Brown2, and M.P. Pender3

1 Department of Neurology, Royal Brisbane and Women’s Hospital, Herston, Queensland, Australia
2 Department of Thoracic Medicine, Royal Brisbane and Women’s Hospital, Herston, Queensland, Australia
3 Department of Neurology, Royal Brisbane and Women’s Hospital, Herston, Queensland, Australia; School of Medicine, The University of Queensland, Brisbane, Queensland, Australia

* To whom correspondence should be addressed.


  Abstract

Apneusis is a disturbance of respiratory rhythm characterized by severely prolonged inspiratory effort, and is caused by bilateral lesions in the dorsal pons. In humans it is most commonly caused by pontine infarction and has rarely been reported in multiple sclerosis (MS). Here we report on a patient with MS who developed episodic apneusis which responded to treatment with buspirone, a serotonin type 1A receptor agonist.

Key Words: apneusis, buspirone, hypoxia, multiple sclerosis, pons, respiratory, serotonin agonist

First published on April 18, 2008, doi:10.1177/1352458507085802

Multiple Sclerosis 2008;14:705.

A more recent version of this article appeared on June 1, 2008

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[Abstract] [Full Text] [PDF]


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