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Multiple Sclerosis
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1352458508088710v1
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Article

Improvement of hand dexterity following motor cortex rTMS in multiple sclerosis patients with cerebellar impairment

G Koch1, S Rossi1, C Prosperetti1, C Codecà1, F Monteleone1, L Petrosini2, G Bernardi1, and D Centonze1

1 Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata, Rome, Italy; Centro Europeo per la Ricerca sul Cervello (CERC)/Fondazione Santa Lucia, Rome, Italy
2 Centro Europeo per la Ricerca sul Cervello (CERC)/Fondazione Santa Lucia, Rome, Italy; Dipartimento di Psicologia, Università La Sapienza, Rome, Italy

* To whom correspondence should be addressed.


  Abstract

We tested the effects of 5-Hz repetitive transcranial magnetic stimulation (rTMS) over the motor cortex in multiple sclerosis (MS) subjects with cerebellar symptoms. rTMS improved hand dexterity in cerebellar patients (n = 8) but not in healthy subjects (n = 7), as detected by a significant transient reduction of the time required to complete the nine-hole pegboard task. rTMS of the motor cortex may be a useful approach to treat cerebellar impairment in MS patients.

Key Words: cerebellum, motor functions, multiple sclerosis, rTMS, transcranial magnetic stimulation

First published on June 23, 2008, doi:10.1177/1352458508088710

Multiple Sclerosis 2008;14:995.

A more recent version of this article appeared on August 1, 2008

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