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Vitamin D receptor gene polymorphism is associated with reduced disability in multiple sclerosis

¹ Keele Multiple Sclerosis Research Group, Department of Neurology, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK
² Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool, UK
³ Human Genomics Research Group, Institute of Science and Technology in Medicine, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK
⁴ Keele Multiple Sclerosis Research Group, Department of Neurology, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK; Human Genomics Research Group, Institute of Science and Technology in Medicine, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK

^* To whom correspondence should be addressed.

	Abstract

Ultraviolet radiation (UVR) may contribute to multiple sclerosis (MS) outcome by a mechanism involving vitamin D and the vitamin D receptor (VDR). In 512 patients with MS duration of 10 or more years, we studied the association of VDR single nucleotide polymorphisms (A/G¹²²⁹, C/G³⁴⁴⁴, G/A³⁹⁴⁴, CC²⁰⁹⁶⁵, CC³⁰⁰⁵⁶, F/f³⁰⁸⁷⁵, C/T⁴⁸²⁰⁰, T/t⁶⁵⁰¹³) with outcome or disability. ff³⁰⁸⁷⁵ frequency was lower in cases with EDSS 6.0 than with scores < 6.0 (odds ratio = 0.38, 95% CI = 0.20–0.70). The association of ff³⁰⁸⁷⁵ with outcome was not mediated by cumulative exposure to UVR as assessed by questionnaire; low exposure (odds ratio = 0.42, 95% CI = 0.14–1.34) and high exposure (odds ratio = 0.34, 95% CI = 0.16–0.73).

Key Words: disability evaluation, EDSS, multiple sclerosis, MSSS, ultraviolet radiation, vitamin D receptor

First published on July 24, 2008, doi:10.1177/1352458508094643

Multiple Sclerosis 2008;14:1280.

A more recent version of this article appeared on November 1, 2008


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