This Article Full Text (OnlineFirst PDF) All Versions of this Article: 1352458508097217v1 1352458508097217v2 15/2/174    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Koutsis, G Articles by Vassilopoulos, D Search for Related Content PubMed PubMed Citation Articles by Koutsis, G Articles by Vassilopoulos, D Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Substance via MeSH Medline Plus Health Information Multiple Sclerosis Social Bookmarking                         What's this?

An APOA1 promoter polymorphism is associated with cognitive performance in patients with multiple sclerosis

Department of Neurology, University of Athens, Aeginition Hospital, Athens, Greece

^* To whom correspondence should be addressed.

	Abstract

Background

Elevated ApoA1 levels have been associated with decreased dementia risk. The A-allele of the APOA1 –75G/A promoter polymorphism has been associated with elevated ApoA1 levels.

Objective

We sought to investigate the effect of the APOA1 –75G/A promoter polymorphism on cognitive performance in patients with multiple sclerosis (MS).

Methods

A total of 138 patients with MS and 43 controls were studied and underwent neuropsychological assessment with Rao's Brief Repeatable Battery and the Stroop test. All patients were genotyped for APOA1.

Results

APOA1 A-allele carriers displayed superior overall cognitive performance compared with non-carriers (P 0.008) and had a three-fold decrease in the relative risk of overall cognitive impairment (OR 0.29, 95% CI 0.11–0.74). Regarding performance on individual cognitive domains, although APOA1 A-allele carriers performed better than non-carriers on all tests, this was significant only for semantic verbal fluency and the Stroop interference task (P 0.036 and 0.018, respectively).

Conclusions

We found an association of the APOA1 –75G/A promoter polymorphism with cognitive performance in MS. This effect was most prominent on semantic verbal fluency and the Stroop interference task.

Key Words: APOA1, cognitive impairment, multiple sclerosis, stroop, verbal fluency

First published on September 19, 2008, doi:10.1177/1352458508097217

Multiple Sclerosis 2009;15:174.

A more recent version of this article appeared on February 1, 2009
This version was published on November 21, 2008


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?