This Article Full Text (OnlineFirst PDF) All Versions of this Article: 1352458508097218v1 15/2/275    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Ziemssen, T Articles by Bär, M Search for Related Content PubMed PubMed Citation Articles by Ziemssen, T Articles by Bär, M Social Bookmarking                         What's this?

Potential side effect of high-dose corticosteroid relapse treatment: acute generalized exanthematous pustulosis (AGEP)

¹ Department of Neurology, Multiple Sclerosis Center, University Clinic Carl Gustav Carus, University of Technology Dresden, Dresden, Germany
² Department of Dermatology, University Clinic Carl Gustav Carus, University of Technology Dresden, Dresden, Germany

^* To whom correspondence should be addressed.

	Abstract

Introduction

High-dose glucocorticosteroids (GC) are the treatment of choice for acute relapses in patients with multiple sclerosis as proven by several controlled clinical trials. The common adverse effects of GC are well known

Case Presentation

In this study, we report on the exceptional case of a young female treated with intravenous high-dose prednisolone for optic neuritis who developed acute generalized exanthematous pustulosis (AGEP). AGEP is a rare cutaneous adverse reaction induced most frequently by antimicrobial or antihypertensive drugs and viral infections. It is characterized by a febrile erythematous and pustular rash and blood granulocytosis.

Conclusion

In our patient, switching to dexamethasone for the next relapse was tolerated well and is an option for treatment. AGEP is a rare adverse effect of carticosteroid treatment.

Key Words: acute generalized exanthematous pustulosis, Multiple sclerosis, steroids

First published on September 19, 2008, doi:10.1177/1352458508097218

Multiple Sclerosis 2009;15:275.

A more recent version of this article appeared on February 1, 2009


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?