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Multiple Sclerosis
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Article

Neuromyelitis optica and multiple sclerosis in sisters

JA Cabrera-Gómez1, L Ramón-Pérez2, A Saiz3, P Llerena-Fernández2, L Fernández-Fernández2, G Ercilla3, D Grass-Fernández1, MA Robinson-Agramonte1, K Romero-García1, R Macías-Betancourt1, R Galvizu-Sánchez1, C Otero-Motolá2, M Sojo-Gómez1, C Aguilar-Arias1, M Rodríguez-Cordero1, and A González-Quevedo4

1 Multiple Sclerosis Society and Multiple Sclerosis Clinic, International Center of Neurological Restoration, Havana, Cuba
2 Neurological Service and Direction Department, Health International Center, La Pradera
3 Laboratory of Experimental Neurology and Immunology, Hospital Clínic Barcelona, Barcelona, Spain
4 Biochemistry Department , Institute of Neurology and Neurosurgery, Havana, Cuba

* To whom correspondence should be addressed.


  Abstract

Introduction

The association of neuromyelitis optica (NMO) and multiple sclerosis (MS) has been reported, but details of the cases were not described. We report two Venezuelan Caucasian sisters with human leukocyte antigen (HLA) typing.

Results

Patient 1 fulfilled McDonald, et al. criteria with HLA A*24; B*07,*15; DRB1*01,*16 (DR2 positive). Patient 2 fulfilled the NMO revised criteria of Wingerchuck, et al. with HLA A*02,*24; B*07,*40; DRB1*04,*08, similar to Canadian aboriginal NMO cases and the Yukpa population from Venezuela.

Conclusion

These cases confirmed the coexistence of NMO and MS in sisters, and further studies are needed to understand the genetic linkage between these diseases.

Key Words: Devic's disease, human leukocyte antigen, multiple sclerosis, neuromyelitis optica, relapsing neuromyelitis optica

First published on October 15, 2008, doi:10.1177/1352458508097921

Multiple Sclerosis 2009;15:269.

A more recent version of this article appeared on February 1, 2009

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