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Angiotensin-converting enzyme (ACE) and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis

¹ Department of Geriatric Medicine, Graduate School of Medicine, Ehime University, Ehime, Japan
² Department of Molecular Cardiovascular Biology and Pharmacology, Graduate School of Medicine, Ehime University, Ehime, Japan
³ Department of Anesthesiology and Resuscitology, Graduate School of Medicine, Ehime University, Ehime, Japan
⁴ Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

^* To whom correspondence should be addressed.

	Abstract

Background

We reported a reduction in the levels of angiotensin II in cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS).

Objective and methods

To clarify the mechanism underlying this reduction, we assayed angiotensin-converting enzyme (ACE) and ACE2 concentrations along with angiotensin II concentrations in CSF samples from 20 patients with MS and 17 controls with non-neurological diseases.

Results

ACE levels were significantly elevated in patients with MS compared with controls (48.42 ± 4.84 vs 44.71 ± 3.9 pg/mL), whereas ACE2 levels were significantly reduced (2.56 ± 0.26 vs 2.78 ± 0.24 pg/mL), acting toward a normalization of angiotensin II levels.

Conclusion

These results further indicate an alteration of the intrathecal renin-angiotensin system in patients with MS.

Key Words: angiotensin-converting enzyme, cerebrospinal fluid, multiple sclerosis, renin-angiotensin system

First published on January 9, 2009, doi:10.1177/1352458508097923

Multiple Sclerosis 2009;15:262.

A more recent version of this article appeared on February 1, 2009


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