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What insights have new imaging techniques given into aggressive forms of MS – different forms of MS or different from MS?

¹ Neuroradiology Unit, Neurological Institute IRCCS "Fondazione C. Mondino," Pavia, Italy
² Multiple Sclerosis Centre, Neurological Institute IRCCS "Fondazione C. Mondino," Pavia, Italy
³ Department of Hematology and Oncology, Hospital Hotel-Dieu, Paris, France
⁴ Department of Neuroscience, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
⁵ Neuroimaging Laboratory, IRCCS "Fondazione Santa Lucia," Rome, Italy

^* To whom correspondence should be addressed.

	Abstract

"Aggressive" multiple sclerosis (MS) is still a challenging diagnosis, in spite of the relevant progresses concerning the comprehension of the disease mechanisms, especially through pathology studies and the advent of conventional magnetic resonance imaging (MRI). Some reviews have been already published on their clinical and therapeutical aspects, but no systematic review is available in literature about the neuroradiological features, using both conventional and advanced techniques. In particular, advanced MRI techniques, namely diffusion-weighted and tensor imaging, magnetization transfer imaging, and proton magnetic resonance spectroscopy, are giving new insights to find specific and appropriate radiological parameters that can help in targeting the diagnosis. We report a review of literature on the neuroradiological findings of aggressive forms of MS, focusing specifically on the role of advanced MRI techniques in the diagnostic phase and during follow-up.

Key Words: aggressive MS, DWI, magnetization transfer, MR spectroscopy, pseudotumoral MS

First published on November 27, 2008, doi:10.1177/1352458508098561

Multiple Sclerosis 2009;15:285.

A more recent version of this article appeared on March 1, 2009


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