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Does multiple sclerosis increase risk of adverse pregnancy outcomes? A population-based study

¹ School of Public Health, Taipei Medical University, Taipei, Taiwan
² Department of Neurology, General Cathay Hospital, Sijhih Branch, Taipei, Taiwan
³ School of Health Care Administration, Taipei Medical University, Taipei, Taiwan

^* To whom correspondence should be addressed.

	Abstract

Objective

To determine whether maternal multiple sclerosis (MS) is associated with increased risk of adverse pregnancy outcomes in an East Asian country by using a nationwide population-based dataset.

Method

This study linked two nationwide population-based datasets, the birth certificate registry and the Taiwan National Health Insurance Research Dataset. We identified a total of 174 women who gave birth from 2001 to 2003, who were diagnosed with MS within the 2 years preceding the index deliveries, together with 1,392 matched women without chronic disease as a comparison cohort. Multivariate logistic regression analyses were performed for estimation.

Results

We found that compared with healthy mothers, MS was independently associated with a 2.25-fold risk of preterm birth (95% CI = 1.37–3.70) and a 1.89-fold (95% CI = 1.30–2.76) higher risk of babies small for gestational age, after adjusting for family income and maternal, paternal, and infant characteristics. Mothers with MS were also more likely to have cesarean deliveries.

Conclusion

Our study documents increased the risk of adverse pregnancy outcomes for mothers with MS, highlighting a need for more intensive monitoring and obstetric care during pregnancy. Future studies should explore the distinct manifestations and mechanisms of MS in diverse ethnic groups, so more complete information can be provided to affected women concerning pregnancy.

Key Words: multiple sclerosis, pregnancy outcome, preterm birth

First published on March 24, 2009, doi:10.1177/1352458508101937

Multiple Sclerosis 2009;15:606.

A more recent version of this article appeared on May 1, 2009


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