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Multiple Sclerosis
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Article

Erythrocyte membrane fatty acids in patients with multiple sclerosis

GM Hon1, MS Hassan1, SJ van Rensburg2, S Abel3, DW Marais4, P van Jaarsveld4, CM Smuts5, F Henning6, RT Erasmus7, and T Matsha1*

1 Department of Bio-Medical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, P O Box 1906, Bellville, 7530, Cape Town, South Africa
2 National Health Laboratory Services, South Africa
3 PROMEC Unit and NIRU, South Africa
4 South African Medical Research Council, South Africa
5 South African Medical Research Council, South Africa; North-West University (Potchefstroom Campus), South Africa
6 Division of Neurology, Tygerberg Academic Hospital, Western Cape, South Africa
7 Division of Chemical Pathology, University of Stellenbosch, South Africa

* To whom correspondence should be addressed.


  Abstract

Background

Reports on fatty acids levels in multiple sclerosis remain inconclusive.

Objective

To determine the erythrocyte membrane fatty acid levels in multiple sclerosis patients and correlate with Kurtzke Expanded Disability Status Scale.

Methods

Fatty acid composition of 31 multiple sclerosis and 30 control individuals were measured by gas chromatography.

Results

The membrane phosphatidylcholine C20:4n – 6 concentration was lower in the multiple sclerosis patients when compared to that of the control group, P = 0.04 and it correlated inversely with the EDSS and FSS.

Conclusion

Decrease in C20:4n – 6 in the erythrocyte membrane could be an indication of depleted plasma stores, and a reflection of disease severity.

Key Words: multiple sclerosis, outcome measurement, relapsing/remitting

First published on May 12, 2009, doi:10.1177/1352458509103321

Multiple Sclerosis 2009;15:759.

A more recent version of this article appeared on June 1, 2009

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