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Pulmonary arterial hypertension associated with interferon beta treatment for multiple sclerosis: a case report

AH Ledinek¹, S Jazbec¹, I Drinovec², and U Rot^1*

¹ Department of Neurology, Medical Centre, Ljubljana, Slovenia
² University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia

^* To whom correspondence should be addressed.

	Abstract

A 23-year-old woman with multiple sclerosis developed respiratory symptoms 3 years after introduction of interferon beta-1b. The diagnosis of pulmonary arterial hypertension (PAH) was established. The patient partially responded to sildenafil and bosetan treatment. This is the first report of PAH, associated with interferon beta therapy. As shown in experimental models, interferon treatment can induce PAH by stimulation of thromboxane cascade and secretion of various inflammatory mediators.

Key Words: interferon beta, multiple sclerosis, pulmonary arterial hypertension, side effects, treatment

First published on May 22, 2009, doi:10.1177/1352458509104593

Multiple Sclerosis 2009;15:885.

A more recent version of this article appeared on July 1, 2009


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