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This version was published on March 1, 2008
Multiple Sclerosis, Vol. 14, No. 2, 188-196 (2008)
DOI: 10.1177/1352458507082143

Serum uric acid levels of patients with multiple sclerosis and other neurological diseases

Fuhua Peng

Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People's Republic of China

Bin Zhang

Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People's Republic of China

Xiufeng Zhong

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center of Sun Yat-Sen University, 54 Xianlie Road, Guangzhou 510060, Guangdong Province, People's Republic of China

Jin Li

Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People's Republic of China

Guihong Xu

Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People's Republic of China

Xueqiang Hu

Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People's Republic of China, huxueqiangzssy{at}yahoo.com.cn

Wei Qiu

Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People's Republic of China

Zhong Pei

Department of Neurology, The First Affiliated Hospital of Sun Yat-Sen University, 89 Zhongshaner Road, Guangzhou 510080, Guangdong Province, People's Republic of China

The serum uric acid (UA) levels were measured in 112 patients with multiple sclerosis (MS) and 794 patients with different types of other neurological diseases (OND) or healthy control group. Serum UA levels, along with relevant clinical parameters of MS and OND, were also investigated. MS patients had significantly lower UA levels than those with transient ischemia attack (344.6 ± 130.6 µmol/L, P = 0.000), cerebral hemorrhage (311.9 ± 104.7 µmol/L, P = 0.000), cerebral infarction (291.3 ± 101.6 µmol/L, P = 0.014) and the healthy control group (312.1 ± 92.8 µmol/L, P = 0.000). MS patients had significantly higher serum UA levels than those with cryptococcus meningitis or meningoencephalitis (178.9 ± 107.0 µmol/L, P = 0.000) and tuberculous meningitis or meningoencephalitis patients (175.7 ± 99.9 µmol/L, P = 0.000). There were no significant differences in UA levels between patients with MS and those with facial neuritis, viral meningitis or encephalitis, pulmonary tuberculosis, polymyositis or dermatomyositis, myasthenia gravis, subarachnoid hemorrhage, migraine, Guillain—Barre syndrome and myelitis. In addition, UA levels were independently correlated with gender and duration of MS, but neither with MRI activity, disability nor subtypes of the disease in MS patients. Our data suggest that UA has two biphasic functions: neuroprotective and injurious. Our studies may help physicians to deal with conditions having abnormal UA levels. Multiple Sclerosis 2008; 14: 188—196. http://msj.sagepub.com

Key Words: multiple sclerosis • neuroprotection • other neurological diseases • treatment • uric acid


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