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This version was published on March 1, 2008
Multiple Sclerosis, Vol. 14, No. 2, 278-283 (2008)
DOI: 10.1177/1352458507082604

Autologous stem-cell transplantation in malignant multiple sclerosis: a case with a favorable long-term outcome

VK Kimiskidis

Department of Neurology , Aristotle University of Thessaloniki, George Papanikolaou Hospital, Thessaloniki, 570 10 Greece, kimiskid{at}med.auth.gr

I. Sakellari

Department of Haematology, Bone Marrow Transplantation Unit, George Papanikolaou Hospital, Thessaloniki, 570 10 Greece

V. Tsimourtou

Department of Neurology , Aristotle University of Thessaloniki, George Papanikolaou Hospital, Thessaloniki, 570 10 Greece

V. Kapina

Department of Neurology , Aristotle University of Thessaloniki, George Papanikolaou Hospital, Thessaloniki, 570 10 Greece

S. Papagiannopoulos

Department of Neurology , Aristotle University of Thessaloniki, George Papanikolaou Hospital, Thessaloniki, 570 10 Greece

D. Kazis

Department of Neurology , Aristotle University of Thessaloniki, George Papanikolaou Hospital, Thessaloniki, 570 10 Greece

N. Vlaikidis

Department of Neurology , Aristotle University of Thessaloniki, George Papanikolaou Hospital, Thessaloniki, 570 10 Greece

A. Anagnostopoulos

Department of Haematology, Bone Marrow Transplantation Unit, George Papanikolaou Hospital, Thessaloniki, 570 10 Greece

A. Fassas

Department of Haematology, Bone Marrow Transplantation Unit, George Papanikolaou Hospital, Thessaloniki, 570 10 Greece

Malignant multiple sclerosis (MS) is a rare but clinically important subtype of MS characterized by the rapid development of significant disability in the early stages of the disease process. These patients are refractory to conventional immunomodulatory agents and the mainstay of their treatment is plasmapheresis or immunosuppression with mitoxantrone, cyclophosphamide, cladribine or, lately, bone marrow transplantation. We report on the case of a 17-year old patient with malignant MS who was treated with high-dose chemotherapy plus anti-thymocyte globulin followed by autologous stem cell transplantation. This intervention resulted in an impressive and long-lasting clinical and radiological response. It is concluded that intensive immunosuppression followed by autologous stem cell transplantation is a viable therapeutic option in patients with malignant MS unresponsive to conventional forms of treatment. Multiple Sclerosis 2008; 17 : 278—283. http://msj.sagepub.com

Key Words: autologous stem-cell transplantation • malignant multiple sclerosis


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