This Article Full Text (PDF) All Versions of this Article: 1352458507084270v1 1352458507084270v2 1352458507084270v3 14/3/364    most recent References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Web of Science (3) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Roca, M. Articles by Correale, J. Search for Related Content PubMed PubMed Citation Articles by Roca, M. Articles by Correale, J. Social Bookmarking                         What's this?

Cognitive deficits in multiple sclerosis correlate with changes in fronto-subcortical tracts

Department of Neurology, Dr Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina

T. Torralva

Department of Neurology, Dr Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina

F. Meli

Department of Radiology, Dr Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina

M. Fiol

Department of Neurology, Dr Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina

ML Calcagno

Department of Statistics, School of Pharmacy and Biochemistry, Buenos Aires University, Buenos Aires, Argentina

S. Carpintiero

Department of Radiology, Dr Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina

G. De Pino

Department of Radiology, Dr Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina

F. Ventrice

Department of Radiology, Dr Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina

ME Martín

Department of Neurology, Dr Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina

L. Vita

Department of Neurology, Dr Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina

F. Manes

Department of Neurology, Dr Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina

J. Correale

Department of Neurology, Dr Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina, jcorreale{at}fleni.org.ar, bairesla{at}fibertel.com.ar

Cognitive function and diffusion tensor imaging were assessed in a group of 12 patients with early relapsing—remitting multiple sclerosis (disease duration 3 years), and mild clinical disability (expanded disability status scale 2), as well as in 12 control subjects. Patients showed impairment in immediate logical memory and delayed recall with the Rey auditory verbal learning test. No significant differences in classical executive tests were observed. In contrast, differences were found for specific executive tests including IOWA Gambling Task, multiple errands test hospital version (MET) and Hotel Task, as well as in Paced-Auditory Serial Addition Test (PASAT). Significant correlation was found between PASAT performance and FA measures (r = 0.64, P = 0.03), the apparent diffusion coefficients and the MET (r = 0.72, P = 0.01), as well as in one subtask of Hotel (r = -0.68, P = 0.02). Thus, executive deficits can best be appreciated at early stages of MS when a more specific battery of tests is used for patient evaluation. In this series, test failures observed correlated with changes in fronto-subcortical fiber tracts. Multiple Sclerosis 2008; 14: 364—369. http://msj.sagepub.com

Key Words: Multiple Sclerosis • Frontal lobe • Cognitive functions • Diffusion tensor MRI

This version was published on April 1, 2008

Multiple Sclerosis, Vol. 14, No. 3, 364-369 (2008)
DOI: 10.1177/1352458507084270


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